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KMID : 0359919930120030377
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Korean Journal of Nephrology
1993 Volume.12 No. 3 p.377 ~ p.384
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Changes of the Erythrocyte Antioxidant System in Anemic patients with Chronic Renal Failure
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Abstract
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Background :
@EN The decreased antioxidant system contribute to peroxidativc damage of erythrocyte and-hange of malondialdehyde level in chronic renal failure patients. This study took in chronic renal failure patients and changes of erythrocyte antioxidant
system
after erythropoieitin therapy.
@ES Methods :
@EN The levels of erythrocyte glutathione, glutathione transferase, SH group catalase and malondialdehyde were examined in twenty-one patients with chronic renal failure undergoing maintenance hemodialysis and sixteen normal control group.
@ES Results :
@EN The levels of erythrocyte total glutathione and total SH group were significantly decreased and malondialdehyde level of catalase, glutathione transferase and non protein SH group were not changed.
Above changes were not different from patients group with erythropoietin treatment and patients group without any treatment for anemia.
@ES Conclusion :
@EN These results suggest that decreased levels of erythrocyte antioxidant system may play an important role in peroxiative damage of erythrocyte and this may be cause of anemia in uremic patient, but erythropoietin therapy does not exert any
influence
on antioxidant system of erythrocyte in uremic patient.
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KEYWORD
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